Sergio Ruiz Llorente
Sergio Ruiz Llorente
Categoría: Profesor/a Ayudante Doctor/a
Departamento: Biomedicina y Biotecnología
Correo electrónico:
Estudios
Grado en Biología (G650)
Grado en Biología Sanitaria (G651)
Grupos de Investigación
Participa en: Daño celular asociado a senescencia - Cell damage associated with senescence.
Líneas de investigación del Grupo
Daño celular asociado a senescencia - Cell damage associated with senescence.
- Caracterizar los mecanismos implicados en daño celular en ancianos y sujetos con patologías asociadas al desarrollo de senescencia precoz.
- Microvesículas endoteliales como biomarcador y potencial diana terapéutica de la enfermedad cardiovascular en la enfermedad renal crónica.
- Papel de las microvesículas producidas en la enfermedad renal crónica en el desarrollo de la enfermedad cardiovascular.
- Papel de microRNAs vehiculados por microvesículas de células senescentes en la enfermedad vascular asociada a la enfermedad renal crónica.
Proyectos de Investigación
No existen datos en este apartado
Libros
No existen datos en este apartado
Capítulos
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RUIZ LLORENTE, Sergio; , Montero-Conde, C; , Ruiz-Llorente, S; , Fagin, JA; "Cáncer de Tiroides". Bases generales y moleculares del cáncer de tiroides de estirpe folicular. 2014. .
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RUIZ LLORENTE, Sergio; , Ruiz-Llorente, S; , Robledo, M; , Cascón, A; "Spanish Society of Medical Oncology (SEOM)". Endocrine tumor syndromes. 2006. p. 447 - 473 .
Artículos
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NAVARRO , Paloma; GRAZIOSO , Tatiana P; BARQUÍN , Arantzazu; BARBA , María; YAGÜE , Mónica; MILLAN , Carlos; LÓPEZ , Irene; SEVILLANO , Elena; QUIRALTE , Miguel; FERNÁNDEZ , Paloma; LOSADA , Diego; CALEIRAS , Eduardo; CALZAS , Julia; , Beatriz Jimenez; RUIZ LLORENTE, Sergio; JUSTO , Juan; GUERRERO , Felix; HEVIA , Vital; MARTÍN , Raquel; PÉREZ RODRÍGUEZ , Francisco José; TEJERINA , Julia; PRIETO , Mario; COMUNE , Paula; RODRÍGUEZ MORENO , Juan Francisco; GARCÍA-DONAS , Jesús; ."Multicenter study correlating molecular characteristics and clinical outcomes of cancer cases with patient-derived organoids.". (ISSN: 0392-9078). Journal of Experimental and Clinical Cancer Research. 2025 .
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RUIZ LLORENTE, Sergio; , Quiralte, M; , Barquín, A; , Sevillano, E; , Navarro, P; , Yagüe, M; , Barba, M; , Rodríguez-Moreno, JF; , Balarezo, A; , Peinado, H; , Izquierdo, E; , García-Donas, J; , Ruiz-Llorente, S; ."Proteomic profiling of peritoneal-derived small extracelullar vesicles from ovarian cancer patients correlates with clinical outcome". The Journal of Clinical Investigation. 2024
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RUIZ LLORENTE, Sergio; , Ruiz-Llorente, S; , Rodríguez-Moreno, JF; , de Velasco, G; , Álvarez-Fernández, C; , Collado-Martín, R; , Fernández, R; , Vázquez-Estévez, S; , Virizuela, JA; , Gajate, P; , Font, A; , Barquín, A; , Laínez, N; , Beltran, L; , Rodríguez-Antona, C; , Berraondo, P; , García-Donas, J; ."Comprehensive molecular characterization of muscle invasive bladder cancer (MIBC) treated with durvalumab and olaparib in the neoadjuvant setting: NEODURVARIB trial". Nature Medicine (enviado, datos presentados en meeting de ASCO GU-2022). 2023
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RUIZ LLORENTE, Sergio; , Barquín, A; , Madurga, R; , Kennedy, K; , Navarro, P; , Villares, P; , Rodríguez-Antona, C; , Ruiz-Llorente, S; , Nistal, E; , Rodríguez-Moreno, M; , Yagüe, M; , Barba, M; , Zanin, M; , Berraondo, P; , García-Donas, J; ."Randomized Phase II Clinical Trial of Ruxolitinib Plus Simvastatin in COVID19 clinical outcome and cytokine evolution". En revisión, Frontiers in Immunology. 2023
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RUIZ LLORENTE, Sergio; , Montero-Conde, C; , Leandro-García, LJ; , Martínez-Montes, A; , Martínez, P; , Moya, FJ; , Letón, R; , Gil, E; , Martínez-Puente, N; , Guadalix, S; , Currás-Freixes, M; , García-Tobar, L; , Zafrón, C; , Jordá, M; , Riesco-Eizaguirre, G; , González-García, P; , Monteagudo, M; , Torres-Pérez, R; , Ruiz-Llorente, S; , Mancikova, V; , Pérez-Martínez, M; , Pita, G; , Galofré, JC; , González-Neira, A; , Cascón, A; , Rodríguez-Antona, C; , Megías, D; , Blasco, MA; , Caleiras, E; , Rodríguez-Perales, S; , Robledo, M; ."Comprehensive molecular analysis of immortalization hallmarks in thyroid cancer reveals new prognostic markers". Clinical and Translational Medicine. 2022
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RUIZ LLORENTE, Sergio; ."MEK inhibitors sensitivity in BRAF fusion-driven prostate cancer". (ISSN: 1699-3055). Clinical and Translational Oncology. 2022
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RUIZ LLORENTE, Sergio; , Bote-Curiel, L; , Ruiz-Llorente, S; , Muñoz-Romero, S; , Yagüe-Fernández, M; , Barquín, A; , García-Donas, J; , Rojo-Álvarez, JL; ."Multivariate feature selection and autoencoder embeddings of ovarian cancer clinical and genetic data". (ISSN: 0957-4174). Expert Systems with Applications. 2022
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RUIZ LLORENTE, Sergio; , Ruiz-Llorente, S; , Bote-Curiel, L; , Muñoz-Romero, S; , Yagüe-Fernández, M; , Barquín, A; , García-Donas, J; , Rojo, JL; ."A Resampling Univariate Analysis Approach to Ovarian Cancer From Clinical and Genetic Data.". (ISSN: 2169-3536). IEEE Access. 2021 , vol 9 , p. 25959 - 25972
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RUIZ LLORENTE, Sergio; KANG , EY; GEORGE , J; POPOVIC , G; MEAGHER , NS; BOLITHON , A; TALHOUK , A; CHIU , DS; ANGLESIO , MS; DA-ANOY , A; LAMBRECHTS , D; LOVERIX , L; SIEL , O; BISINOTTO , C; , García-Donas J; , Ruiz-Llorente S; , Yagüe-Fernández M; EDWARDS , RP; ELISHAEV , E; OLAWAIYE , A; TAYLOR , S; ATASEVEN , B; DU BOIS , A; HARTER , P; LESTER , J; HOGDALL , CK; ARMASU , SM; HUANG , Y; VIERKANT , RA; WANG , C; WINHAM , SJ; HEUBLEIN , S; KOMMOS , FKF; CRAMER , DW; SASAMOTO , N; WAGENSVELD , I; LYCKE , M; PEARCE , CL; MATEOUI , C; PIKE , MC; TSENG , CC; BILIC , S; LEUNG , Y; STEWART , C; TAN , A; YU , Y; BOROS , J; BRAND , AH; HARNETT , PR; KENNEDY , CJ; NEVINS , N; MORGAN , T; FASCHING , PA; VERGOTE , I; SWERDLOW , AJ; DOS REIS , FJC; MAXWELL , GL; NEUHAUSEN , SL; , Barquín-García A; MODUGNO , F; MOYSICH , KB; CROWE , P; HIRASAWA , A; HEITZ , F; KARLAN , BY; GOODE , EL; SINN , P; HORLINGS , H; HOGDALL , E; SUNDFELDT , K; KOMMOS , S; STAEBLER , A; WU , AH; COHEN , P; DE FAZIO , A; LEE , CH; STEED , H; LE , ND; COOK , LS; RAMUS , SJ; KELEMEN , LE; KOBEL , M; ."MCM3 is a novel proliferation marker associated with longer survival for patients with tubo-ovarian high grade serous carcinoma". Virchows Archive. 2021 , vol Nov , num 15
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RUIZ LLORENTE, Sergio; , Bote-Curiel, L; , Ruiz-Llorente, S; , Muñoz-Romero, S; , Yagüe-Fernández, M; , Barquín, A; , García-Donas, J; , Rojo-Álvarez, JL; ."Text Analytics and Mixed FeatureExtraction in Ovarian Cancer Clinical and Genetic Data.". (ISSN: 2169-3536). IEEE Access. 2021 , p. 58034 - 58051
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RUIZ LLORENTE, Sergio; , Ruiz-Llorente, S; , Garcia-Carpizo, V; , Sarmentero, J; , Barrero, MJ; , González-Corpas, A; ."CREBBP/EP300 Bromodomain Inhibition Affects the Proliferation of AR-Positive Breast Cancer Cell Lines". (ISSN: 1541-7786). Molecular Cancer Research. 2019 , p. 720 - 730
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RUIZ LLORENTE, Sergio; , Ruiz-Llorente, S; , Garcia-Carpizo, V; , Sarmentero, J; , Graña-Castro, O; , Barrero, MJ; , Pisano, DG; ."CREBBP/EP300 bromodomains are critical to sustain the GATA1/MYC regulatory axis in proliferation.". Epigenetics & Chromatin. 2018 , vol 11 , num 1
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RUIZ LLORENTE, Sergio; , Montero-Conde, C; , Leandro-García, LJ; , Chen, X; , Ruiz-Llorente, S; , Oler, G; , Ryder, M; , Landa, I; , Sánchez-Vega, FA; , La,K; , Ghossein, RA; , Bajorin, DF; , Knauf, JA; , Riordan, JD; , Dupuy, AJ; , Fagin, JA; ."Transposon mutagenesis identifies chromatin modifiers cooperating with Ras in thyroid tumorigenesis and detects ATXN7 as a cancer gene". PNAS. 2017 , vol 114 , num 25 , p. E4951 - E4960
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RUIZ LLORENTE, Sergio; , Garcia-Carpizo, V; , Sarmentero, J; , Han, B; , Ruiz-Llorente, S; , Graña, O; , Pisano, DG; , Serrano, M; , Brooks, HB; , Campbell, RM; , Barrero, MJ; ."NSD2 contributes to oncogenic RAS-driven transcription in lung cancer cells through long-range epigenetic activation.". Scientific Reports. 2016 , vol 8 , num 6 , p. 32952 -
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RUIZ LLORENTE, Sergio; , Landa, I; , Boullosa, C; , Inglada-Perez, L; , Sastre-Perona, A; , Pastor, S; , Velázquez, A; , Ruiz-Llorente, S; , Mancikova, V; , Schiavi, F; , Marcos, R; , Malats, N; , Opocher, G; , Díaz-Uriarte, R; , Santisteban, P; , Valencia, A; , Robledo, M; ."An epistatic interaction between the PAX8 and STK17B genes in papillary thyroid cancer susceptibility". PlosOne. 2013 , vol 8 , num 9 , p. e74765 -
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RUIZ LLORENTE, Sergio; , Montero-Conde, C; , Ruiz-Llorente, S; , Domínguez, J; , Knauf, JA; , Viale, A; , Sherman, EJ; , Ryder, M; , Ghossein, RA; , Fagin, JA; , Rosen, N; ."Relief of feedback inhibition of HER3 transcription by RAF and MEK inhibitors attenuates their antitumor effects in BRAF-mutant thyroid carcinomas". Cancer Discovery. 2013 , vol 3 , num 5 , p. 520 - 533
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RUIZ LLORENTE, Sergio; , Choi, HJ; , Ruiz-Llorente, S; , Kim, TY; , Jeon, MJ; , Han, JM; , Kim, WG; , Shong, YK; , Bae Kim, W; ."Alpha-lipoic acid induces sodium iodide symporter expression in TPC-1 thyroid cancer cell line". Nucl. Med. Biol.. 2012 , vol 39 , num 8 , p. 1275 - 1280
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RUIZ LLORENTE, Sergio; , Ruiz-Llorente, S; , Carrillo Santa de Pau, E; , Sastre-Perona, A; , Montero-Conde, C; , Gomez-Lopez, G; , Fagin, J. A; , Valencia, A; , Pisano, DG; , Santisteban, P; ."Genome-wide analysis of Pax8 binding provides new insights into thyroid functions". (ISSN: 1471-2164). BMC Genomics. 2012 , vol 13 , p. 147 - 147
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RUIZ LLORENTE, Sergio; , Ruiz-Llorente, S (COAUTOR); , Montero-Conde, C; , Landa, I (COAUTOR); , Inglada-Perez, L; , Schiavi, F; , Leskela, S; , Pita, G; , Milne, R; , Maravall, J; , Ramos, I; , Andia, V; , Rodriguez-Poyo, P; , Jara-Albarran, A; , Meoro, A; , del Peso, C; , Arribas, L; , Iglesias, P; , Caballero, J; , Serrano, J; , Pico, A; , Pomares, F; , Gimenez, G; , Lopez-Mondejar, P; , Castello, R; , Merante-Boschin, I; , Pelizzo, MR; , Mauricio, D; , Opocher, G; , Rodríguez-Antona, C; , González-Neira, A; , Matias-Guiu, X; , Santisteban, P; , Robledo, M; ."The variant rs1867277 in FOXE1 gene confers thyroid cancer susceptibility through the recruitment of USF1/USF2 transcription factors". PLoS Genet.. 2009 , vol 5 , num 9 , p. e1000637 - e1000637
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RUIZ LLORENTE, Sergio; , Ruiz-Llorente, S; , Montero-Conde, C; , Milne, RL; , Moya, CM; , Letón, R; , Cebrian, A; , Cascón, A; , Mercadillo, F; , Landa, I; , Borrego, S; , Perez de Nanclares, G; , Alvarez-Escola, C; , Diaz-Perez, JA; , Carracedo, A; , Urioste, M; , González-Neira, A; , Benitez, J; , Santisteban, P; , Dopazo, J; , Ponder, BA; , Robledo, M; ."Association study of 69 genes in the ret pathway identifies low-penetrance loci in sporadic medullary thyroid carcinoma". Cancer Res.. 2007 , vol 67 , num 19 , p. 9561 - 9567
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RUIZ LLORENTE, Sergio; , Cascón, A; , Montero-Conde, C; , Escobar, B; , Rodríguez-Antona, C; , Ruiz-Llorente, S; , Osorio, A; , Mercadillo, F; , Letón, R; , Campos, JM; , Garcia-Sagredo, JM; , Benitez, J; , Malumbres, M; , Robledo, M; ."Loss of the actin regulator HSPC300 results in clear cell renal cell carcinoma protection in Von Hippel-Lindau patients". Hum. Mutat.. 2007 , vol 28 , num 6 , p. 613 - 621
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RUIZ LLORENTE, Sergio; , Cascón, A; , Montero-Conde, C; , Ruiz-Llorente, S; , Mercadillo, F; , Letón, R; , Rodríguez-Antona, C; , Martinez-Delgado, B; , Delgado, M; , Diez, A; , Rovira, A; , Diaz, JA; , Robledo, M; ."Gross SDHB deletions in patients with paraganglioma detected by multiplex PCR: a possible hot spot?". Genes Chromosomes Cancer. 2006 , vol 45 , num 3 , p. 213 - 219
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RUIZ LLORENTE, Sergio; , Ruiz-Llorente, S (COAUTOR); , Cascon, A (COAUTOR); , Rodríguez-Perales, S; , Honrado, E; , Martinez-Ramirez, A; , Montero-Conde, C; , Letón, R; , Benitez, J; , Dopazo, J; , Cigudosa, JC; , Robledo, M; ."A novel candidate region linked to development of both pheochromocytoma and head/neck paraganglioma". Genes Chromosomes Cancer. 2005 , vol 42 , num 3 , p. 260 - 268
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RUIZ LLORENTE, Sergio; , Cascón, A; , Cebrian, A; , Pollan, M; , Ruiz-Llorente, S; , Montero-Conde, C; , Letón, R; , Gutierrez, R; , Lesueur, F; , Milne, RL; , Gonzalez-Albarran, O; , Lucas-Morante, T; , Benitez, J; , Ponder, BA; , Robledo, M; ."Succinate dehydrogenase D variants do not constitute a risk factor for developing C cell hyperplasia or sporadic medullary thyroid carcinoma". J. Clin. Endocrinol. Metab.. 2005 , vol 90 , num 4 , p. 2127 - 2130
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RUIZ LLORENTE, Sergio; , Ruiz-Llorente, S (COAUTOR); , Cascon, A (COAUTOR); , Fraga, M. F.; , Leton, R.; , Telleria, D.; , Sastre, J.; , Diez, JJ; , Martinez Diaz-Guerra, G; , Benitez, J; , Diaz Perez, JA; , Esteller, M; , Robledo, M; ."Genetic and epigenetic profile of sporadic pheochromocytomas". J. Med. Genet.. 2004 , vol 41 , num 3 , p. e30 - e30
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RUIZ LLORENTE, Sergio; , Ruiz-Llorente, S; , Bravo, J; , Cebrian, A; , Cascón, A; , Pollan, M; , Telleria, D; , Letón, R; , Urioste, M; , Rodriguez-Lopez, R; , de Campos, JM; , Munoz, MJ; , Lacambra, C; , Benitez, J; , Robledo, M; ."Genetic characterization and structural analysis of VHL Spanish families to define genotype-phenotype correlations". Hum. Mutat.. 2004 , vol 23 , num 2 , p. 160 - 169
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RUIZ LLORENTE, Sergio; , Conde, L; , Vaquerizas, JM; , Santoyo, J; , Ruiz-Llorente, S; , Al-Shahrour, F; , Robledo, M; , Dopazo, J; ."PupaSNP Finder: a web tool for finding SNPs with putative effect at transcriptional level". Nucleic Acids Res.. 2004 , vol 32 , num Web Server issue , p. W242 - 248
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RUIZ LLORENTE, Sergio; , Robledo, M; , Fernandez, RM; , Antinolo, G; , Ruiz-Llorente, S; , Pecina, A; , Eng, C; , Borrego, S; ."The RET IVS1-126G>T variant is strongly associated with the development of sporadic medullary thyroid cancer". Thyroid. 2004 , vol 14 , num 4 , p. 329 - 331
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RUIZ LLORENTE, Sergio; , Ruiz-Llorente, S (COAUTOR); , Cascon, A (COAUTOR); , Cebrian, A; , Letón, R; , Telleria, D; , Robledo, M; , Benitez, J; ."G12S and H50R variations are polymorphisms in the SDHD gene". Genes Chromosomes Cancer. 2003 , vol 37 , num 2 , p. 220 - 221
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RUIZ LLORENTE, Sergio; , Rodríguez-Perales, S; , Melendez, B; , Martinez-Delgado, B; , Robledo, M; , Otero, I; , Martinez-Ramirez, A; , Ruiz-Llorente, S; , Urioste, M; , Cigudosa, JC; , Benitez, J; ."Molecular study of a new family with hereditary renal cell carcinoma and a translocation t(3;8)(p13;q24.1)". Hum. Genet.. 2003 , vol 112 , num 2 , p. 178 - 185
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RUIZ LLORENTE, Sergio; , Cebrian, A; , Ruiz-Llorente, S; , Cascón, A; , Pollan, M; , Diez, JJ; , Pico, A; , Telleria, D; , Benitez, J; , Robledo, M; ."Mutational and gross deletion study of the MEN1 gene and correlation with clinical features in Spanish patients". J. Med. Genet.. 2003 , vol 40 , num 5 , p. e72 - e72
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RUIZ LLORENTE, Sergio; , Robledo, M; , Pollan, M; , Gil, L; , Cebrian, A; , Ruiz, S; , Azanedo, M; , Benitez, J; , Menarguez, J; , Rojas, JM; ."Polymorphisms G691S/S904S of RET as genetic modifiers of MEN2A". Cancer Res.. 2003 , vol 63 , num 8 , p. 1814 - 1817
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RUIZ LLORENTE, Sergio; , Ruiz-Llorente, S; , Arancha, C; , Cascón, A; , Osorio, A; , Benitez, J; , Martinez-Delgado, B; , Robledo, M; ."A rapid and easy method for multiple endocrine neoplasia type 1 mutation detection using conformation-sensitive gel electrophoresis". J. Hum. Genet.. 2002 , vol 47 , num 4 , p. 190 - 195
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RUIZ LLORENTE, Sergio; , Cascón, A; , Ruiz-Llorente, S; , Cebrian, A; , Telleria, D; , Rivero, JC; , Diez, JJ; , Lopez-Ibarra, PJ; , Jaunsolo, MA; , Benitez, J; , Robledo, M; ."Identification of novel SDHD mutations in patients with phaeochromocytoma and/or paraganglioma". Eur. J. Hum. Genet.. 2002 , vol 10 , num 8 , p. 457 - 461
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RUIZ LLORENTE, Sergio; , Cascón, A; , Cebrian, A; , Ruiz-Llorente, S; , Telleria, D; , Benitez, J; , Robledo, M; ."SDHB mutation analysis in familial and sporadic phaeochromocytoma identifies a novel mutation". J. Med. Genet.. 2002 , vol 39 , num 10 , p. E64 - E64
Artículos Electrónicos
No existen datos en este apartado
Congresos
No existen datos en este apartado
Tesis
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QUIRALTE PULIDO, Miguel; "Perfiles proteómicos de exosomas peritoneales para la identificación de marcadores pronósticos y predictivos en carcinomas ováricos". Director: RUIZ LLORENTE, Sergio, , García-Donas, J, . Universidad San Pablo CEU. Fecha de lectura: 01/07/2023. .